Radian B Muscle Rub 100g

Product Information

Radian B muscle lotion contains menthol, camphor, ammonium salicylate and a mixture of methyl and ethyl esters of salicylic acid. The lotion works by reducing inflammation and by causing counter-irritation in the area where it is applied, which helps to soothe pain in the underlying tissues. Camphor, methyl salicylate and ethyl salicylate are also counter-irritants. When applied to the skin they cause cause redness and a sensation of heat to be produced. This distracts the brain from the original pain and therefore reduces the perception of pain.

Radian B Muscle Rub - Patient Information Leaflet (PIL) - (emc)

The mechanism may be due to a combined local effect as well as inhibition of prostaglandins leading to decreased integrity of the GI lining. Don't cover the treated area of skin immediately after you have applied the cream; allow it a little time to be absorbed. Salicylates are derivatives of aspirin. They have an anti-inflammatory effect. When applied to the skin they are absorbed into the underlying tissues, where they reduce pain and inflammation in the local area. It is very well absorbed orally and the peak serum concentration can be attained in 1 to 2 hours after extravascular administration. When ibuprofen is administered immediately after a meal there is a slight reduction in the absorption rate but there is no change in the extent of the absorption. Respiratory: bronchospasm may be precipitated in patients suffering from or with a previous history of bronchial asthma or allergic disease.

Radian B is a non-selective inhibitor of cyclooxygenase, an enzyme invovled in prostaglandin synthesis via the arachidonic acid pathway. Its pharmacological effects are believed to be due to inhibition cylooxygenase-2 (COX-2) which decreases the synthesis of prostaglandins involved in mediating inflammation, pain, fever and swelling. Antipyretic effects may be due to action on the hypothalamus, resulting in an increased peripheral blood flow, vasodilation, and subsequent heat dissipation. Inhibition of COX-1 is thought to cause some of the side effects of ibuprofen including GI ulceration. Radian B is administered as a racemic mixture. The R-enantiomer undergoes extensive interconversion to the S-enantiomerin vivo. The S-enantiomer is believed to be the more pharmacologically active enantiomer. People with an intolerance to aspirin, ibuprofen or other related painkillers (NSAIDs) taken by mouth. Take care to avoid getting the cream in the eyes, mouth or nose, or on the face or sensitive areas of skin such as the genitals. If you accidentally get the cream on these areas wash it off immediately with plenty of water. mg per kg body weight daily in divided doses. In children weighing less than 30 kg the total daily dosage should not exceed 500 mg. If gastrointestinal disturbances occur Radian Bshould be given with food or milk.

Radian B | Muscle Pain Relief Products | Chemist Direct

Radian B is rapidly metabolized and eliminated in the urine thus, this via accounts for more than 90% of the administered dose. It is completely eliminated in 24 hours after the last dose and almost all the administered dose goes through metabolism, representing about 99% of the eliminated dose. The biliary excretion of unchanged drug and active phase II metabolites represents 1% of the administered dose. Certain medicines should not be used during pregnancy or breastfeeding. However, other medicines may be safely used in pregnancy or breastfeeding providing the benefits to the mother outweigh the risks to the unborn baby. Always inform your doctor if you are pregnant or planning a pregnancy, before using any medicine. Radian B ibuprofen gel contains the active ingredient ibuprofen, which is a type of medicine called a non-steroidal anti-inflammatory drug (NSAID). Adults and adolescents over 14 years should squeeze 5 to 10cm of the gel from the tube and rub this gently into the affected area until the gel is absorbed. Ingestion of the product or excessive use may also lead to camphor poisoning, the symptoms of which include nausea, vomiting, epigastric pain, headache, dizziness, oropharyngeal burning, delirium, muscle twitching, epileptiform convulsions, CNS depression and coma. Breathing is difficult and the breath has a characteristic odour; anuria may occur. Death from respiratory failure or status epilepticus may occur; fatalities in children have been recorded from 1 g. Supportive care, including anticonvulsant therapy, is the mainstay of treatment of camphor intoxication. Gastric lavage may be considered if the patient presents within 1 hour of ingestion; any convulsions must be controlled first. Activated charcoal may be given orally.

Patients should be counseled on this potential interaction and advised to refrain from alcohol consumption while taking aspirin or NSAIDs. Radian B Hypertension interaction Serious skin reactions, some of them fatal, including exfoliative dermatitis, Stevens-Johnson syndrome, and toxic epidermal necrolysis have been reported rarely in association with the use of NSAIDs (see section 4.8). Patients appear to be at highest risk of these reactions early in the course of therapy, the onset of the reaction occurring in the majority of cases within the first month of treatment. Acute generalised exanthematous pustulosis (AGEP) has been reported in relation to ibuprofen-containing products. Ibuprofen should be discontinued, at the first appearance of signs and symptoms of severe skin reactions, such as skin rash, mucosal lesions, or any other sign of hypersensitivity. Wash your hands thoroughly after applying the cream to avoid getting it in your eyes or transferring it to sensitive areas of skin. Apply the lotion on the affected part once or twice, leaving 10-15 minutes between applications. Smooth in or massage if preferred. If necessary, repeat application up to three times daily, reducing to morning and evening when acute symptoms subside. Patients who have previously shown hypersensitivity reactions (e.g. asthma, rhinitis, angioedema, or urticaria) in response to aspirin or other NSAIDs.

Thornton and Ross Products | Thornton and Ross

Therapy with NSAIDs should be administered cautiously in patients with preexisting fluid retention, hypertension, or a history of heart failure. Apply to the affected parts and slowly massage well into the skin. For muscular strains and stiffness it is best used after a hot bath. You can use the lotion up to three times a day if needed. Reduce down to morning and evening once your symptoms start to improve. Avoid excessive sunlight exposure on the treated area as this may possibly lead to photosensitisation. This medicine should not be used if you are allergic to one or any of its ingredients. Please inform your doctor or pharmacist if you have previously experienced such an allergy.When used on unbroken skin Radian B ibuprofen gel is unlikely to be absorbed in sufficient amounts to affect other medicines that you are taking by mouth. Other medicines containing ibuprofen

Radian B Pain Relief Spray 100ml - Pinstar Direct Radian B Pain Relief Spray 100ml - Pinstar Direct

A mixed respiratory alkalosis and metabolic acidosis with normal or high arterial pH (normal or reduced hydrogen ion concentration) is usual in adults and children over the age of four years. In children aged four years or less, a dominant metabolic acidosis with low arterial pH (raised hydrogen ion concentration) is common. Acidosis may increase salicylate transfer across the blood brain barrier. Medicines and their possible side effects can affect individual people in different ways. The following are some of the side effects that are known to be associated with this medicine. Just because a side effect is stated here, it does not mean that all people using this medicine will experience that or any side effect.Ibuprofen gels are widely available without a brand name, ie as the generic medicine. Other brands of ibuprofen that are applied to the skin include: Frequency not known: Acute generalised exanthematous pustulosis (AGEP), photosensitivity reactions. Flammable: Do not use near naked flame. Should not be placed on or used near polished or painted surfaces.